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This open-label clinical study enrolled 10 adults with attenuated Mucopolysaccharidosis II and advanced disease under the direction of the Japan Society for Research on Mucopolysaccharidosis Disorders prior to regulatory approval of idursulfase in Japan. Ten male patients, ages years, received weekly intravenous infusions of 0. Significant reductions in lysosomal storage and several clinical improvements were observed during the study mean changes below. Urinary glycosaminoglycan excretion decreased rapidly within the first three months of treatment and normalized in all patients by study completion Liver and spleen volumes also showed rapid reductions that were maintained in all patients through study completion Improvements were noted in the 6-Minute Walk Test

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SOD was founded in December [1] by Ganari Takahashi , who retired from the company in March and is currently working in agriculture. For the fiscal year ending March 31, , SOD had total sales of For the figures were sales of

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